MEDIATOR COMPLEX PROXIMAL TAIL SUBUNIT MED30 IS CRITICAL FOR MEDIATOR CORE STABILITY AND CARDIOMYOCYTE TRANSCRIPTIONAL NETWORK.

Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network.

Dysregulation of cardiac transcription programs has been identified in patients and families with heart failure, as well as those with morphological and functional forms of congenital heart defects.Mediator is a multi-subunit complex that plays a central role in transcription initiation by integrating regulatory signals from gene-specific transcrip

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Wilson loop algebras and quantum K-theory for Grassmannians

Abstract We study the algebra of Wilson line operators better waters xl7000 in three-dimensional N $$ mathcal{N} $$ = 2 supersymmetric U(M ) gauge theories with a Higgs phase related to a complex Grassmannian Gr(M, N ), and its connection to K-theoretic Gromov-Witten invariants for Gr(M, N ).For different Chern-Simons levels, the Wilson loop algebr

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Study protocol: a mixed-methods study to evaluate which health visiting models in England are most promising for mitigating the harms of adverse childhood experiences

Introduction Exposure to adverse childhood experiences (ACEs) is associated with poorer health outcomes throughout life.In England, health visiting is a long-standing, nationally implemented service that aims to prevent and mitigate the impact of adversity in early childhood, including for children exposed to ACEs.A range of health visiting service

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